How Revero Treats Autoimmune and Inflammatory Conditions

Autoimmune and inflammatory conditions occur when the body's immune system mistakenly attacks its tissues as if they were a threat. Inflammation is usually a protective and healing response to infections or injuries. However, when it becomes chronic, it can lead to autoimmune diseases where the immune system continuously targets healthy tissues.

Common autoimmune conditions include rheumatoid arthritis, lupus, and multiple sclerosis. These conditions involve inflammation that can damage various parts of the body, including joints and organs. They can also trigger neurodegenerative diseases.

The Impact of Autoimmune and Inflammatory Conditions

Autoimmune and inflammatory conditions affect millions of people:

• About 20% of Americans have an autoimmune disease.
• Chronic inflammation impacts nearly 125 million Americans and plays a role in over 50% of all deaths in the U.S.
• Rheumatoid arthritis affects about 1.3 million Americans, causing significant disability.
• Psoriasis impacts over 8 million people in the U.S.
• Over 500,000 Americans have Crohn's disease.
• Up to 15% of U.S. adults suffer from Irritable Bowel Syndrome (IBS).

How an Unhealthy Diet Contributes to Inflammation

Certain foods can worsen inflammation and contribute to autoimmune conditions. Here are some key dietary factors.

Phytotoxins and antinutrients

Phytotoxins are chemicals produced by plants to protect themselves. While not all are harmful, some can cause inflammation and health problems. Antinutrients can irritate the gut, disrupt cell functions, or trigger immune responses, leading to inflammation.

Some nuts and other foods contain oxalates, which can form crystals in the body, causing an inflammatory immune response. Because a low-carb diet can include foods that contain oxalates, it is important to limit how much of these foods are consumed.

Lectins are another common phytotoxin in legumes, certain fruits, and vegetables. Lectins can damage the gut lining, leading to inflammation and increased autoimmunity.

How Phytotoxins Cause Inflammation

Phytotoxins affect cells and promote inflammation through several actions, including causing cellular damage. Phytotoxins can damage the cell membrane or interfere with cell function, causing inflammatory responses.

Cells have receptors on their membrane that trigger an immune response as if the cell were dialing 911. Phytotoxins can activate these responses and trigger more inflammation, recruiting additional immune cells to the site of inflammation.

Phytotoxins can interfere with the delicate balance of gut bacteria, which also causes inflammation. Harmful bacteria can get the upper hand while beneficial ones will suffer losses. This promotes the release of additional toxins into the gut, causing more inflammation.

Plant phytotoxins can sometimes trigger oxidative stress as well as inflammation. These changes affect how the cell produces energy for its needs, and may cause cell death.

By interacting with inflammation signaling pathways, phytotoxins can cause inflammatory or autoimmune conditions.

Gluten

Gluten is the major protein in wheat, barley, and rye. It is a molecule that is extremely challenging for the human digestive tract to digest. Gluten also triggers an immune response that can cause damage to the small intestine. This damage destroys the villi that line the intestine and is an autoimmune condition known as celiac disease.

Even without celiac disease, some people still react to gluten with symptoms like bloating, diarrhea, fatigue, and joint pain.

Gluten can cause changes to the intestinal gut lining which increases gut permeability. This allows harmful particles, such as food particles or bacterial fragments, to enter the bloodstream and cause inflammation.

Gluten breaks down into molecules called peptides. Peptides such as gliadins resemble other proteins in the body and can trigger an inflammatory or autoimmune response. This response is known as molecular mimicry.

Dairy

The carbohydrate in dairy is known as lactose and requires the enzyme lactase for proper digestion. Some people lose the ability to form lactase as adults, while in others the ability to form this enzyme persists into adulthood. Lactose intolerance is the result of the failure to produce lactase.

Lack of the enzyme to digest lactose can cause digestive issues such as bloating, gas, or diarrhea after consuming dairy products. If the lactose isn’t digested in the small intestine, it is fermented by gut bacteria in the large intestine.

Dairy products include a protein called casein. Some people react to A1 casein in cow's milk, triggering an inflammatory immune response in the gut. This immune response can cause bloating, pain, diarrhea, and fatigue. A similar response can occur to other dairy proteins such as whey protein.

Dairy products include naturally occuring hormones and bioactive molecules, which may promote hormonal Imbalances. These hormones and related molecules in dairy can disrupt human hormones and trigger inflammation.

Seed Oils

Seed oils are usually called vegetable oils, although they are not made from vegetables but from seeds. Examples of seed oils include canola, soybean, sunflower, and corn oil. These oils are very high in Omega-6 Fatty Acids. Consuming them will cause an imbalance in the ratio of omega-6 to omega-3 oils, promoting more inflammation and disease.

Seed oils should be considered processed food, as they are extensively processed with chemicals and heating. As a result of this processing, seed oils often contain harmful compounds like trans fats and oxidized lipids, which can also trigger inflammation.

Leaky Gut

The intestinal membrane is a gateway that restricts the absorption of undigested food or bacteria while facilitating the absorption of vital nutrients released by digestion. When gluten attacks the gut lining, it becomes more permeable. Harmful substances such as food particles or bacterial fragments known as lipopolysaccharides (LPS) can enter the bloodstream.

The body responds with a strong immune response, causing systemic inflammation. The antibodies that result cross-react with various tissues in the body. This can lead to autoimmune responses as the immune system attacks these foreign particles. The process is an example of molecular mimicry.

Gut Imbalance, SIBO, Candida

A high-carb diet promotes the growth of harmful bacteria and yeast, disrupting gut bacteria and resulting in an imbalance in immune function. This happens through several mechanisms.

The consumption of dietary sugars and processed foods feeds harmful bacteria that thrive on sugar. This overgrowth of yeasts like Candida and other harmful bacteria can also suppress the growth of beneficial gut bacteria. The resulting imbalance is known as dysbiosis

Normally, the small intestine has very few bacteria compared to the massive gut microbiome colony that exists in the large intestine. A high-carbohydrate diet can result in small intestine bacterial overgrowth (SIBO). Bacteria overgrowth in the small intestine causes bloating and digestive issues. Candida yeast growth can lead to fatigue, yeast infections, and digestive problems.

FODMAPs

FODMAPs (Fermentable Oligosaccharides Disaccharides Monosaccharides And Polyols) are a type of carbohydrate that is poorly absorbed and can cause bloating and diarrhea, especially in people with IBS. These foods include onions, wheat, artichokes, apples, and yogurt. In a susceptible person, these foods cause water to move into the bowels, resulting in bloating, gas, pain, and diarrhea.

Gut bacteria will also ferment FODMAPs, producing gas that further distends the gut and abdomen, causing pain. The combination of fluid, gas, and fermenting irritates the gut lining, resulting in abdominal pain and discomfort in susceptible individuals.

Insulin Resistance

A high intake of carbs and sugars can promote higher insulin and blood glucose levels. This can lead to insulin resistance and type 2 diabetes. These changes also trigger the elevation of triglycerides and inflammatory response.

A high-carbohydrate diet activates the immune system and stimulates the release of pro-inflammatory compounds. Oxidative stress and inflammation damage cells and tissues, increasing the risk of developing or worsening inflammatory diseases.

Hormonal Disruptions

Phytotoxins are naturally occurring defensive toxins in plants. They can disrupt our hormone balance by mimicking or blocking natural hormones or binding to hormone receptors. When phytotoxins bind to cellular hormone receptors, they can also block hormonal function.

Phytotoxins can also interfere with the synthesis or breakdown of hormones, resulting in more imbalances in bodily functions.

Goitrogens are an example of a phytotoxin. These are found in soy and cruciferous vegetables and can interfere with thyroid function. The thyroid tries to compensate by enlarging, resulting in the condition known as goiter.

Phytoestrogens are another common phytotoxin found in soy and flaxseeds. Phytoestrogens can mimic estrogen and disrupt hormonal balance. These changes in hormonal function can worsen inflammation.

Revero’s Approach to Reducing Inflammation

Revero uses a low-carbohydrate diet to treat inflammation and autoimmune conditions. This diet is also personalized to address allergens, phytochemicals, and processed foods that promote inflammation.

Eliminating phytotoxins and allergens by cutting out foods such as grains and legumes reduces inflammatory phytotoxins. These phytotoxins include oxalates, lectins, and phytates which cause malabsorption of minerals and inflammatory changes.

Avoiding processed foods, refined carbohydrates, and sugars helps eliminate foods that contribute to inflammation. These processed and sweet foods also often contain unhealthy oils and additives that can trigger inflammatory responses.

Eliminating gluten, dairy, and other inflammatory foods has been shown to reduce the symptoms of autoimmune diseases like psoriasis.

Revero Is Designed to Restore Gut Health and Improve Nutritional Status

Ultra-processed foods, grains, and other phytotoxins can penetrate and disrupt the gut lining. This triggers inflammatory and autoimmune activity which leads to diseases. A low-carb diet helps to preserve the integrity of the gut wall and membrane. This diet eliminates these irritants while supporting a healthy microbiome.

Improving nutritional status is another benefit of the Revero diet. The diet emphasizes nutrient-rich foods like meats and non-starchy vegetables that provide complete nutrition in the most bioavailable forms. These foods are rich in anti-inflammatory omega-3 fatty acids, which helps to combat oxidative stress and inflammation.

Revero also reduces FODMAPs for individuals with irritable bowel syndrome, because eliminating these has been shown to help with inflammatory bowel disease.

Revero Is Designed to Restore Metabolic Health, Limit Pro-inflammatory Pathways, and Restore Hormonal Balance

A low-carb diet eliminates foods that cause spikes in blood sugar and insulin levels. Reduced insulin levels minimize inflammation in the body by improving insulin resistance, reducing the activation of pro-inflammatory pathways, and lowering oxidative stress. It also helps lower blood pressure, improve blood flow, and reduce vascular inflammation.

A low-carb diet can also positively influence hormone regulation by eliminating some reactive foods and stabilizing blood glucose, which help regulate hormones in a variety of ways:

• Reducing insulin levels
• Balancing hunger and satiety hormones like leptin and ghrelin
• Lowering cortisol levels
• Supporting thyroid function
• Balancing sex hormones
• Potentially increasing testosterone levels
• Reducing inflammation
• Improving sleep quality
• Regulate brain neurotransmitters and improve mood and overall mental health
• By reducing phytotoxins from grains and legumes that can interfere with hormones, a low carb diet helps improve hormonal health.

Revero Is Designed to Induce Ketosis and Improve Brain Function

A low-carb diet further helps reduce inflammation by putting you in ketosis. Ketone bodies have anti-inflammatory properties. They act like mini fire extinguishers in your body. Ketones fight inflammation by inhibiting the production of inflammatory molecules.

Ketone bodies also help reduce oxidative stress and clean up harmful free radicals, which helps to protect the brain from neurodegenerative disease, ischemia, physical trauma, or psychological stress.

A low-carb diet also helps to strengthen the intestinal gut barrier, regulate intestinal permeability, and improve gut bacteria.

Being in a state of nutritional ketosis helps your brain’s mitochondria to multiply and improve their function. This increases the brain's ability to access energy, stabilizing function while protecting vital brain cells.

The benefits of these changes include cognitive improvement and reduced inflammation and oxidative stress in the brain. These changes are known to be of benefit in neurodegenerative diseases.

The improved stability of brain networks that results from energetic improvement helps to improve mental clarity and focus.

A Root Cause Approach for Treating Inflammatory and Autoimmune Diseases

Revero’s nutrition therapy is designed to treat the cause of inflammation and autoimmune disease by utilizing a low-carbohydrate diet that eliminates many causes of inflammation.

When the immune system has become triggered by a food or food group, identifying the food sensitivities and removing the foods that cause systemic inflammation and autoimmune reactions are critical steps to treating the condition.

Using a low-carbohydrate approach, the Revero diet is designed to reduce inflammation by removing grains and sugars that cause elevated glucose, insulin, and inflammation.

This approach promotes weight loss in overweight or obese people, providing many health benefits without the risk, expense, and inconvenience of pharmaceutical treatment.